Glyphosate: risk or threat to human health and wild life
DOI:
https://doi.org/10.29312/remexca.v15i5.3342Keywords:
environmental damage, glyphosate, herbicideAbstract
Glyphosate is the most used herbicide worldwide in agriculture over the past 20 years. Its use has led to side effects with direct damage to ecosystems, wildlife, and human health. Much of the world’s scientific community has joined the task of researching the effects of this herbicide and documenting sustainable alternatives to reduce its use. There are contradictions in the scientific literature in this regard, so it was proposed to carry out a meta-analysis of the scientific information in order to identify the effects derived from the use of glyphosate on human health and the environment. A systematic search of the Scopus database was conducted from 2014 to 2022. It was found that the main metabolite aminomethylphosphonic acid and the surfactant polyoxyethyl amine are present in the commercial formulation of Roundup® (glyphosate), are persistent and present toxicity in different tissues and organs of terrestrial and aquatic species, in addition to decreasing agricultural production by affecting the growth of seedlings. Other positions point out that glyphosate does not cause effects or exhibit toxicity. However, these claims lack credibility because of the type of compound used in toxicity bioassays. This review concludes that, for eminently precautionary purposes, it is necessary to reduce the use of this agrochemical in agriculture, the long-term effect of which puts human health and biota at risk. And, therefore, the need to generate regulations that control their use or restriction.
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Ait-Bali, Y.; Kaikai, N.; Ba-M’hamed, S. and Bennis, M. 2019. Learning and memory impairments associated to acetylcholinesterase inhibition and oxidative stress following glyphosate based-herbicide exposure in mice. Toxicology. 415:18-25. https://doi.org/10.1016/j.tox.2019.01.010.
Ait-Bali, Y.; Ba-M’hamed, S.; Gambarotta, G.; Sassoè-Pognetto, M.; Giustetto, M. and Bennis, M. 2020. Pre-and postnatal exposure to glyphosate-based herbicide causes behavioral and cognitive impairments in adult mice: evidence of cortical ad hippocampal dysfunction. Archives of Toxicology. 5(94):1703-1723. https://doi.org/10.1007/s00204-020-02677-7.
CEDRSSA. 2020. Centro de para el Desarrollo Rural Sustentable y la Soberanía Alimentaria. Impacto del uso de plaguicidas en el sector agropecuario. México.
Chávez-Ortiz, P.; Tapia-Torres, Y.; Larsen, J. and García-Oliva, F. 2021. Glyphosate-based herbicides alter soil carbon and phosphorus dynamics and microbial activity. Applied Soil Ecology. 104256(169):1-14. https://doi.org/10.1016/j.apsoil.2021.104256.
Cházaro-Olvera, S.; Solorzano-López, D. M.; Montoya-Mendoza, J.; Castañeda-Chávez, M. R. and Lango-Reynoso, F. 2022. Acute toxicity of diuron and glyphosate in megalopae of Callinectes sapidus from the Jamapa River Estuary, Veracruz. Latin American Journal of Aquatic Research. 4(50):610-617. http://dx.doi.org/10.3856/vol50-issue4-fulltext-2891.
Chen, Y.; Chen, W. J.; Huang, Y.; Li, J.; Zhong, J.; Zhang, W.; Zou, Y.; Mishra, S.; Bhatt, P. and Chen, S. 2022. Insights into the microbial degradation and resistance mechanisms of glyphosate. Environmental Research. 1(215):114153. https://doi.org/10.1016/j.envres.2022.114153.
Crall, J. 2022. Glyphosate impairs bee thermoregulation. Science. 376(6597):1051-1052. https://doi.org/10.1126/science.abq5554.
Cuhra, M.; Bøhn, T. and Cuhra, P. 2016. Glyphosate: too much fa good thing? Frontiers in Environmental Science. 28(4):1-14. https://doi.org/10.3389/fenvs.2016.00028.
De María, M.; Silva, S. C.; Kroll, K. J.; Walsh, M. T.; Nouri, M. Z.; Hunter, M. E.; Ross, M.; Clauss, T. M. and Denslow, N. D. 2021. Chronic exposure to glyphosate in Florida manatee. Environment International. 152(106493):1-11. https://doi.org/10.1016/j.envint.2021.106493.
DOF. 2020. Diario Oficial de la Federación. Decreto por el que se establecen las acciones que deberán realizar las dependencias y entidades que integran la Administración Pública Federal, en el ámbito de sus competencias, para sustituir gradualmente el uso, adquisición, distribución, promoción e importación de la sustancia química denominada glifosato y de los agroquímicos utilizados en nuestro país que lo contienen como ingrediente activo, por alternativas sostenibles y culturalmente adecuadas, que permitan mantener la producción y resulten seguras para la salud humana, la diversidad biocultural del país y el ambiente. https://www.dof.gob.mx/nota-detalle.php?codigo=5609365&fecha=31/12/2020 #gsc.tab=0
Faria, M.; Bedrossiantz, J.; Ramírez, J. R. R.; Mayol, M.; García, G. H.; Bellot, M.; Prats, E.; García-Reneyro, N.; Gómez-Canela, C.; Gómez-Oliván, L. M. and Raldúa, D. 2021. Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety. Environment International. 06253(146):1-10. https://doi.org/10.1016/j.envint.2020.106253.
Fluegge, K. and Fluegge, K. 2016. Glyphosate use predicts healthcare utilization for ADHD in the healthcare cost and utilization project net (HCUPnet): a two-way fixed-effects analysis. Polish Journal of Environmental Studies. 4(25):1489-1503. https://doi.org/10.15244/pjoes/61742.
Fortes, C.; Mastroeni, S.; Segatto, M. M.; Hohmann, C.; Miligi, L.; Bakos, L. and Bonamigo, R. 2016. Occupational exposure to pesticides with occupational sun exposure increases the risk for cutaneous melanoma. Journal of Occupational and Environmental Medicine. 4(58):370-375. https://doi.org/10.1097/JOM.0000000000000665.
Fuhrimann, S.; Farnham, A.; Staudacher, P.; Atuhaire, A.; Manfioletti, T.; Niwagaba, C. B.; Namirembe, S.; Mugweri, J.; Winkler, M. S.; Portengen, L.; Kromhout, H. and Mora, A. M. 2021. Exposure to multiple pesticides and neurobehavioral outcomes among smallholder farmers in Uganda. Environment International. 152(106477):1-10. https://doi.org/10.1016/j.envint.2021.106477.
Gomes, M. P.; Manac’h, S. G. L.; Maccario, S.; Labrecque, M.; Lucotte, M. and Juneau, P. 2016. Differential effects of glyphosate and aminomethylphosphonic acid (AMPA) on photosynthesis and chlorophyll metabolism in willow plants. Pesticide Biochemistry and Physiology. 30:65-70. https://doi.org/10.1016/J.PESTBP.2015.11.010
Grondona, S.; Massone, H.; González, M. and Bedmar, F. 2022. Evaluación del peligro de contaminación del agua subterránea en áreas agrícolas. Revista internacional de contaminación ambiental. 38:111-125. https://doi.org/10.20937/rica.54194.
Hao, Y.; Zhang, Y.; Ni, H.; Gao, J.; Yang, Y.; Xu, W. and Tao, L. 2019. Evaluation of the cytotoxic effects of glyphosate herbicides in human liver, lung, and nerve. Journal of Environmental Science and Health, Part B. 9(54):737-744. https://doi.org/10.1080/03601234.2019.163321.
Kier, L. D. and Kirkland, D. J. 2013. Review of genotoxicity studies of glyphosate and glyphosate-based formulations. Critical Reviews in Toxicology. 4(43):283-315. https://doi.org/10.3109/10408444.2013.770820.
Lee, J.; Choi, Y.; Park, S.; Gil, H. W.; Song, H. and Hong, S. Y. 2017. Serum S100 protein could predict altered consciousness in glyphosate or glufosinate poisoning patients. Clinical Toxicology. 5(55):357-359. https://doi.org/10.1080/15563650.2017.1286013.
Liao, Y.; Berthion, J. M.; Colet, I.; Merlo, M.; Nougadère, A. and Hu, R. 2018. Validation and application of analytical method for glyphosate and glufosinate in foods by liquid chromatography-tandem mass spectrometry. Journal of Chromatography. 1549:31-38. https://doi:10.1016/j.chroma.2018.03.036.
Lima, I. B.; Boëchat, I. G.; Fernandes, M. D.; Monteiro, J. A. F.; Rivaroli, L. and Gücker, B. 2022. Glyphosate pollution of surface runoff, stream water, and drinking water resources in Southeast Brazil. Environmental Science and Pollution Research. 10(30):27030-27040. https://doi.org/10.1007/s11356-022-24167-2.
Lopes, A.; Benvindo, S. M.; Carvalho, W. F.; Nunes, H. F.; De Lima, P. N.; Costa, M. S.; Benetti, E. J.; Guerra, V.; Saboia, M. S. M. T.; Santos, C. E.; Simões, K.; Bastos, R. P. and De Melo, E. S. D. 2021. Evaluation of the genotoxic, mutagenic, and histopathological hepatic effects of polyoxyethylene amine (POEA) and glyphosate on Dendropsophus minutus tadpoles. Environmental Pollution. 289(117911):1-10. https://doi.org/10.1016/j.envpol.2021.117911.
Lu, J.; Wang, W.; Zhang, C.; Xu, W.; Chen, W.; Tao, L.; Li, Z.; Cheng, J. and Zhang, Y. 2022. Characterization of glyphosate-induced cardiovascular toxicity and apoptosis in zebrafish. Science of the total Environment. 851(158308):1-26. https://doi.org/10.1016/j.scitotenv.2022.158308.
Martínez, A. and Al-Ahmad, A. J. 2018. Effects of glyphosate and aminomethylphosphonic acid on an isogeneic model of the human blood-brain barrier. Toxicology Letters. 304:39-49. https://doi.org/10.1016/j.toxlet.2018.12.013.
Martínez, M. A.; Rodríguez, J. L.; López-Torres, B.; Martínez, M.; Martínez, L. M. R.; Maximiliano, J. E.; Anadón, A. and Ares, I. 2020. Use of human neuroblastoma SH-SY5Y cells to evaluate glyphosate-induced effects on oxidative stress, neuronal development and cell death signaling pathways. Environment International. 105414(135):1-17. https://doi.org/10.1016/j.envint.2019.105414.
Meftaul, I. M.; Venkateswarlu, K.; Dharmarajan, R.; Annamalai, P.; Asaduzzaman, M.; Parven, A. and Megharaj, M. 2020. Controversies over human health and ecological impacts of glyphosate: Is it to be banned in modern agriculture? Environmental Pollution. 114372(263):1-18. https://doi.org/10.1016/j.envpol.2020.114372.
Mesnage, R. and Antoniou, M. N. 2017. Facts and fallacies in the debate on Glyphosate Toxicity. Front Public Health. 316(5):1-7. https://doi.org/10.3389/fpubh.2017.00316.
Mesnage, R.; Ferguson, S.; Brandsma, I.; Moelijker, N.; Zhang, G.; Mazzacuva, F.; Caldwell, A.; Halket, J. and Antoniou, M. N. 2022. The surfactant co-formulant POEA in the glyphosate-based herbicide RangerPro but not glyphosate alone causes necrosis in Caco-2 and HepG2 human cell lines and ER stress in the ToxTracker assay. Food and Chemical Toxicology. 168(113380):1-8. https://doi.org/10.1016/j.fct.2022.113380.
Mink, P. J.; Mandel, J. S.; Sceurman, B. K. and Lundin, J. L. 2012. Epidemiologic studies of glyphosate and cancer: A review. Regulatory Toxicology and Pharmacology. 3(63):440-452. https://doi.org/10.1016/j.yrtph.2012.05.012.
Moreno, N. C.; Sofia, S. H. and Martínez, C. B. 2014. Genotoxic effects of the herbicide Roundup Transorb and its active ingredient glyphosate on the fish Prochilodus lineatus. Environmental Toxicology and Pharmacology. 1(37):448-454. https://doi.org/10.1016/j.etap.2013.12.012.
Motta, E. V. S.; Raymann, K. and Moran, N. A. 2018. Glyphosate perturbs the gut microbiota of honey bees. Proceedings of the National Academy of Sciences. 41(115):10305-10310. https://doi.org/10.1073/pnas.1803880115.
Novotny, E. 2022. Glyphosate, roundup and the failures of regulatory. Assessment Toxics. 321(10):1-14. https://doi.org/10.3390/toxics10060321.
Pavan, F. A.; Samojeden, C. G.; Rutkoski, C. F.; Folador, A.; Da Fré, S. P.; Müller, C.; Hartmann, P. A. and Hartmann, M. T. 2021. Morphological, behavioral and genotoxic effects of glyphosate and 2,4-D mixture in tadpoles of two native species of South American amphibians. Environmental Toxicology and Pharmacology. 85:1-11. https://doi.org/10.1016/j.etap.2021.103637.
Rendón von, O. J. and Dzul-Caamal, R. 2017. Glyphosate residues in Groundwater, drinking water and urine of subsistence farmers from intensive Agriculture Localities: A survey in Hopelchén, Campeche, Mexico. Int. J. Environ. Res. Public Health. 14(595)1-13. https://doi:10.3390/ijerph14060595.
Rosenbaum, K. K.; Miller, G. L.; Kremer, R. J. and Bradley, K. W. 2014. Interactions between glyphosate, Fusarium infection of common waterhemp (Amaranthus rudis), and soil microbial abundance and diversity in soil collections from Missouri. Weed Science. 1(62):71-82. https://doi.org/10.1073/pnas.1803880115.
Seehaus, M. S.; Sasal, M. C.; Van Opstal, N.; Gabioud, E. A.; Wilson, M. G.; Wingeyer, A.; Michlig, M. P. y Repetti, M. R. 2020. Análisis del efecto de secuencias de cultivo sobre el escurrimiento superficial y pérdidas de suelo y herbicidas. Fave. Sección Ciencias Agrarias. 2(19):77.90.
Tarboush, N. A.; Almomani, D. H.; Khabour, O. F. and Azzam, M. I. 2022. Genotoxicity of Glyphosate on cultured human Lymphocytes. International Journal of Toxicology. 2(41):126-131. https://doi.org/ 10.1177/10915818211073514.
Thompson, T. S.; Van den Heever, J. P. and Limanowka, R. E. 2019. Determination of glyphosate, AMPA, and glufosinate in honey by online solid-phase extraction-liquid chromatography-tandem mass spectrometry. Food Additives & Contaminants: Part A. 36:434-446. https://doi.org/10.1080/19440049.2019.1577993.
Villamar-Ayala, C. A.; Carrera-Cevallos, J. V.; Vásquez-Medrano, R. and Espinoza-Montero, P. J. 2019. Fate, eco-toxicological characteristics, and treatment processes applied to water polluted with glyphosate: A critical review. Critical Reviews in Environmental Science and Technology. 16(49):1476-1514. https://doi.org/10.1080/10643389.2019.1579627.
Von Ehrenstein, O. S.; Ling, C.; Cui, X.; Cockburn, M.; Park, A. S.; Yu, F.; Wu, J. and Ritz, B. 2019. Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population-based case-control study. BMJ. 364(1962):1-10. https://doi.org/10.1136/bmj.l962.
Xing, C.; Chen, S.; Wang, Y.; Pan, Z.; Zou, Y.; Sun, S.; Ren, Z. and Zhang, Y. 2022. Glyphosate exposure deteriorates oocyte meiotic maturation via induction of organelle dysfunctions in pigs. Journal of Animal Science and Biotechnology. 13(1):1-14. https://doi.org/10.1186/s40104-022-00732-0.
Young, F.; Ho, D.; Glynn, D. and Edwards, V. 2015. Endocrine disruption and cytotoxicity of glyphosate and roundup in human JAr cells in vitro. Integrative Pharmacology, Toxicology and Genotoxicology. 1(2):70-76. https://doi.org/10.15761/IPTG.1000114.
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